clinical radiation oncology indications techniques and results

william small


this fully updated and enhanced third edition offers a highly practical, application-based review of the biological basis of radiation oncology and the clinical efficacy of radiation therapy. * revised edition of the classic reference in radiation oncology from dr. c.c. wang, whose practical approach to clinical application was legendary * includes the latest developments in the field: intensity modulated radiation therapy (imrt), image guided radiation therapy, and particle beam therapy * includes two brand new chapters palliative radiotherapy, and statistics in radiation oncology * features a vibrant and extremely comprehensive head and neck section * provides immediately applicable treatment algorithms for each tumorshow more

holland frei cancer medicine

robert c. bast


holland-frei cancer medicine, ninth edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. this all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. * a translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease * an emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies * cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics * concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs * includes free access to the wiley digital edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updatesshow more

textbook of uncommon cancer

derek raghavan


the fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. * encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce * fully revised with new material and an evidence-based, teach-by-example approach * provides insight on real-world decision making in the clinical setting * edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview * extensively illustrated in full color throughout, including heat maps to show gene expressionshow more

male breast cancer 2017

ian fentiman


this book provides an up-to-date review of the risk factors and genetics influencing the development of this rare disease. this volume presents clinical features and recent advances in histopathology and molecular profiling are analyzed, providing a valuable aid to clinicians in tailoring treatment to both the patient and the tumour. readers will find important insights into the most effective strategies for making or negating a diagnosis of mbc. within this timely volume, consideration is also given to the psychological needs of men with breast cancer alongside a discussion of the most effective support methods. the surgical management of the disease is examined, together with algorithms for local and systemic therapy. owing to the problem of late diagnosis in mbc, many men have advanced or disseminated disease at diagnosis and, as such, the evidence-based management of these cases is reviewed. male breast cancer concludes with a discussion on determining prognosis and the likely future developments in mbc with a focus on improved diagnosis and survival.
male breast cancer will be of interest to breast surgeons, oncologists, breast radiologists, breast histopathologists and breast care nurses more

image based computer assisted radiation therapy

hidetaka arimura


this book provides a comprehensive overview of the state-of-the-art computational intelligence research and technologies in computer-assisted radiation therapy based on image engineering. it also traces major technical advancements and research findings in the field of image-based computer-assisted radiation therapy. in high-precision radiation therapies, novel approaches in image engineering including computer graphics, image processing, pattern recognition, and computational anatomy play important roles in improving the accuracy of radiation therapy and assisting decision making by radiation oncology professionals, such as radiation oncologists, radiation technologists, and medical physicists, in each phase of radiation therapy. all the topics presented in this book broaden understanding of the modern medical technologies and systems for image-based computer-assisted radiation therapy. therefore this volume will greatly benefit not only radiation oncologists and radiologists but also radiation technologists, professors in medical physics or engineering, and engineers involved in the development of products to utilize this advanced more

molecular targeted therapy of lung cancer

yuichi takiguchi


this book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. it clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. it also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. edited and authored by opinion leaders, molecular targeted therapy of lung cancer provides a comprehensive overview of the disease and its treatments. it is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further more

radiobiology self assessment guide

jennifer yu


radiobiology self-assessment guide a companion to the radiation oncology self-assessment guide and physics in radiation oncology self-assessment guide is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. it covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. to foster retention of key concepts and data, the resource utilizes a user-friendly flash cards; question and answer format with over 700 questions. the questions are supported by detailed answers and rationales along with reference citations for source information.

the guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination; aspects of basic radiobiology covered include fundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included; focused and authoritative, this must-have review provides the expertise of faculty from the department of radiation oncology at the cleveland clinic taussig cancer institute and lerner research institute.

key features:

provides a comprehensive study guide for the radiation and cancer biology portion to the radiation oncology board examincludes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like reviewincludes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agentscontent provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology more

devita hellman and rosenbergs cancer principles and practice of oncology review 2

m.d. ramaswamy govindan; m.d. daniel morgensztern
>prepare for the oncology boards with confidence this comprehensive review book closely follows the contents of devita, hellman, and rosenberg s cancer: principles and practice of oncology, 10th edition, including brand-new, state-of-the-art topics. hundreds of multiple choice and case-based questions cover medical, radiation, and surgical oncology, as well as hematology, diagnosis and staging, molecular biology, immunotherapy, targeted therapy, and more. the questions are also available online in an interactive format, allowing you to study and review anytime, anywhere

  • all questions have been completely revised to mimic the common formats you ll see on the exam.
  • detailed answers with explanations are provided for every question, helping you understand the how and why behind each correct response.
  • content reflects the most current information from the leading oncology text, with corresponding chapters to devita, hellman, and rosenberg s cancer: principles and practice of oncology, 10th edition provided for further review.

now with the print edition, enjoy the bundled interactive ebook edition, which can be ed to your tablet and smartphone or accessed online and includes features like:

  • complete content with enhanced navigation
  • powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web
  • cross-linked pages, references, and more for easy navigation
  • highlighting tool for easier reference of key content throughout the text
  • ability to take and share notes with friends and colleagues
  • quick reference tabbing to save your favorite content for future use

management of soft tissue sarcoma 2016

murray brennan


management of soft tissue sarcoma, 2nd edition provides the most comprehensive analysis of demographics and natural history currently available for these lesions, based on the authors' experience with over 10,000 patients. sections regarding radiation therapy not found in the previous text have been expanded, as have updates on molecular characteristics of sarcomas and chemotherapy studies published since the prior edition. clinical and molecular diagnoses are addressed, and tumor histopathology is employed as the basis of treatment recommendations including surgery, radiation and systemic therapy. this is the first book to provide specific chemotherapy opinions for every sarcoma subtype. written by four world-renowned experts, this book gives a practical, up-to-date approach to managing the many subtypes of adult soft tissue sarcoma. reviews from the first edition: "this is an impressive book. written by a surgeon, a pathologist and an oncologist, the book draws heavily on the memorial sloan-kettering cancer center soft tissue sarcoma (sts) database…it is a book that should be in the library of any sarcoma unit and will appeal to the sub-specialist in orthopaedic oncology."
(robert u. ashford, european journal of orthopaedic surgery & traumatology, vol. 24, 2014) "the book is laid out in 27 chapters, with an impressive inclusion of a wide array of sarcoma histology. one of the real strengths of the book is the quality and number of images, figures, tables, and graphs…the overall outline of the text is well done…this book is a unique and important addition to the sarcoma literature…this edtion should find itself on every medical oncologist's bookshelf …" (larry c. daugherty and sanjay p. bagaria, journal of radiation oncology, vol. 3, 2014)show more

lung cancer 2016 treatment and research

karen l. reckamp


this book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. the text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. this leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. the coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. the book presents insights from experts across disciplines to emphasize the importance of collaborative care. advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung more

induction chemotherapy 2016 systemic and locoregional

karl reinhard aigner


this book presents the full range of management techniques and practices used in induction chemotherapy – both systemic and locoregional – by experienced international groups within one accessible volume. it provides the latest information on the pioneering and cutting-edge practices employed in different institutions and documents the advantages of integrated treatment schedules. all those responsible for treating patients with locally advanced cancers may find new, interesting aspects of locoregional cancer management and will find this book to be an invaluable source of up-to-date information. throughout the world, induction chemotherapy is being used as part of an integrated plan of management for locally advanced, solid tumors, while systemic chemotherapy is most commonly used to shrink primarily non-operable tumors. in cases of poorly or nonresponsive tumors, attempts have been made to administer chemotherapeutics via the arterial route in order to achieve higher localized drug exposure and response rates. such therapies are being practiced worldwide in independent, remote departments in universities, teaching hospitals and clinical schools.
frequently, however, these teams remain relatively unaware of the work being done in other institutions, which may slow further more

immunotherapy of cancer 2016 an innovative treatment comes of age

yoshiyuki yamaguchi


this timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. this innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. the progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the united states. today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. following american approval, many clinical trials of cancer immunotherapy are being conducted.
with this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. the great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient more

image guided stereotactic radiosurgery 2016 high precision non invasive treatment of solid tumors

harun badakhshi


this book provides the reader with a detailed update on the use of stereotactic radiosurgery (srs) in patients with lesions of the brain and other parts of the body. the aim is not simply to explain the application of srs and document its value with reference to the author's own clinical experiences and other published evidence, but also to contextualize the technology within a new strategic concept of cancer care. when embedded within an appropriate conceptual framework, technology becomes pivotal in changing therapeutic strategies. a new paradigm that is increasingly impacting on clinical practice is the oligometastatic state, on the basis that long-term survival might be achieved in patients with a low volume and number of metastatic lesions. this book accordingly addresses the value of srs in patients with oligometastases of solid tumors to the brain, lung, spine, and liver. in addition, it examines the use of srs in patients with diverse brain lesions, early-stage stage lung cancer, liver cancer, and early-stage prostate cancer.
readers will be persuaded that srs, using cutting-edge imaging technologies to deliver precisely targeted radiation therapy, represents an exciting non-invasive procedure that holds great promise for the present and the future of cancer more

hyperthermic oncology from bench to bedside 2016

toshikazu yoshikawa


this comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. it also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer. in the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (emt), resulting in the prevention of metastasis. it also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. the chapters here from expert contributors describe the details of their research for each type of cancer. this book provides not only an overview and the current status of hyperthermia but also its future perspectives. therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of more

thyroid cancer a comprehensive guide to clinical management

leonard wartofsky


thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. expertly edited by drs. leonard wartofsky and douglas van nostrand, this gold standard reference is divided into 11 parts: general considerations on thyroid cancer; general considerations on nuclear medicine; the thyroid nodule; well-differentiated thyroid cancer; variants of thyroid cancer, undifferentiated tumors: medullary thyroid carcinoma; undifferentiated tumors: thyroid lymphoma; undifferentiated tumors: anaplastic thyroid cancer; new frontiers and future directions; and additional resources. with exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as spect/ct, radioiodine ablation (with or without recombinant human tsh), stunning, dosimetry (with or without recombinant human tsh), octreotide and fdg-pet scanning and other alternative imaging modalities.
there is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. in addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (ct), positron emission tomography (pet) and magnetic resonance imaging (mri). an indispensable reference source with chapters written by the field's leading authoritative experts, thyroid cancer: a comprehensive guide to clinical management, third edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid more

hepatocellular carcinoma 2016 diagnosis and treatment

brian i. carr


* hepatocellular carcinoma (hcc) used to be regarded as a rare disease. however, the increasing numbers of chronic hcc carriers in the u.s. and subsequent increased incidences of hcc seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. during this exciting time in the field of hcc basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. suddenly, there are several new choices of therapy to offer patients. hepatocellular carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. this comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying hcc development.
updated and enhanced from the last edition in 2009, hepatocellular carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform hcc incidence and perhaps also the therapy. this cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists. "this is a well written text and should be a good reference book for those who see patients with hcc.." – practical gastroenterology "…a useful tool for both physicians and surgeons with a specific interest in the management of patients with hcc." – digestive and liver diseaseshow more

the molecular basis of human cancer 2017

william b. coleman


this book covers the concepts of molecular medicine and personalized medicine. subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. these chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. the volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. the molecular basis of human cancer, second edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with more

head and neck cancer 2016 multimodality management

jacques bernier


this second edition provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks.
in comparison with the first edition, head and neck cancer, second edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment more

supportive cancer care 2016

david alberts


this textbook provides a highly coordinated, interdisciplinary model for future clinical cancer supportive care programs in national cancer institute (nci)-designated clinical and comprehensive cancer centers and nci community oncology research programs (ncorps). at the same time, it is intended to serve as an up-to-date resource for oncologists and primary care providers that addresses the many aspects of supportive care associated with cancer survivorship. accordingly, the book covers a wide range of areas and topics, including but not limited to patient navigation, psychosocial oncology, patient and family education, lifestyle change counseling, palliative care, symptom management (eg. pain control), cancer risk and genetic counseling, and financial more

features and management of the pelvic cancer pain 2016

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this book focuses on the features of pelvic pain in the different cancer diseases, the pain assessment tools, as well as the pharmacological and non-pharmacological approaches. pelvic cancer pain is a common and debilitating symptom, and pain control is a one among the main therapeutic goals throughout the duration of the disease. because pelvic cancer pain due to primitive cancer, recurrence or metastasis is a complex clinical pathology, no single technique is often guaranteed to produce a complete pain relief. thus, there are many treatment options, but in most cases a correct approach to pain control should be provided by a multidisciplinary team under the responsibility of a pain specialist coordinating several professionals. this book will aid several figures of practitioners, like anesthesiologists, oncologists or surgeons, in making the correct decisions in individual patients affected by cancer pain due to pelvic more

skin care in radiation oncology 2016 a practical guide

barbara fowble


this book serves as a practical guide for the prevention and treatment of radiation dermatitis. skin toxicity caused by radiation treatment is common among cancer patients and minimizing the frequency and severity of these reactions improves quality of life and prevents interruptions that can compromise local-regional control. each chapter is devoted to a specific disease site, such as the head and neck, breast, gastrointestinal, genitourinary, gynecologic, and central nervous system. pediatric malignancies and wound care for locally advanced cancers are also discussed. for each topic, the range and frequency of the observed skin reactions, factors influencing these reactions, the typical course of each reaction and its resolution, and the interventions used are presented. this book provides evidence where it exists for the specific interventions and an extensive illustration program depicts the various reactions and their response to treatment protocols.
skin care in radiation oncology: a practical guide presents a framework for patient care in an era of advancing technology and systemic and targeted therapies and is a valuable resource for radiation oncologists, dermatologists, and more

short course breast radiotherapy 2016 a comprehensive review of hypofractionation partial breast and intra operative irradiation

douglas w. arthur


this comprehensive handbook on the implementation of short course radiotherapy for the treatment of breast cancer is intended as an up-to-date resource for the clinician. the book opens with a series of chapters on underlying principles and diverse relevant topics, including pathologic anatomy of early-stage breast cancer, radiobiology of accelerated breast irradiation, quality assurance and radiation safety, surgical considerations in partial breast irradiation, and impact of oncoplastic surgery on adjuvant radiotherapy. individual sections are then devoted to hypofractionated whole breast radiotherapy, accelerated partial breast irradiation, and intraoperative radiotherapy. each section includes details of patient selection, physics, techniques, data, and toxicity. the reader is provided with clear guidance on the appropriate use of accelerated forms of adjuvant radiotherapy for treatment of early-stage breast cancer and on various emerging treatment more

re irradiation new frontiers 2017

carsten nieder


this book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. in addition, disease specific chapters document recent clinical results and future research directions. all chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. the book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites.
professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective more

rare hereditary cancers 2016 diagnosis and management

chris jacobs


this book approaches the differential diagnosis and management of rare, hereditary cancer syndromes from a practical angle, addressing the issues pertinent to each tumour type as encountered by health professionals in their day-to-day practice. this book enables readers to correctly identify patients with rare cancer syndromes who would benefit from genetic counselling and testing, and provides the necessary knowledge for appropriate patient management and advising at-risk family members. it begins by describing recent advances in genetic testing for cancer-predisposing genes. leading experts from europe and australia then offer detailed, up-to-date guidance on the diagnosis and management of a wide range of hereditary cancers. the concluding chapter examines the wider issues that are raised by genetic testing for rare cancer syndromes for patients, families and health professionals. this book is an invaluable source of information for all specialists involved in the care of such patients and their more

rare genitourinary tumors 2016

lance pagliaro


rare genitourinary tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. a valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. the practical treatment guidelines included for each tumor type are written by experts and fully more

principles and practice of radiotherapy techniques in thoracic malignancies 2016

gokhan ozyigit


this evidence-based guide on the use of radiotherapy in patients with common malignancies of the lung, esophagus, and thymus will help radiation oncologists to deliver optimal care within a multidisciplinary setting. detailed information is provided on all aspects, from delineation of tumor volumes and organs at risk based on four-dimensional ct simulation through to the various advanced radiotherapy techniques, including stereotactic ablative radiotherapy (sabr), intensity-modulated radiation therapy (imrt), tomotherapy, volumetric modulated arc therapy (vmat), and proton therapy. contouring, treatment planning, and treatment delivery are documented in a range of everyday cases, with illustrations of slice-by-slice delineations on planning ct images and finalized treatment plans based on detailed acceptance criteria. numerous practical tips are highlighted, and relevant information is included on surgical techniques and systemic therapies. the book will facilitate decision making in the management of patients with common thoracic malignancies and assist in overcoming the challenges encountered in daily clinical more

plasma cell dyscrasias 2017

aldo m. roccaro


this book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. the plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (mgus), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and waldenstrom's macroglobulinemia. in the case of multiple myeloma, the coverage ranges from genomic aberrations and micrornas to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. the book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell more

managing cancer during pregnancy 2016

hatem a. azim


this book provides hands-on information on how to manage pregnant cancer patients in clinical practice. in this context a multidisciplinary perspective is essential, and contributions are accordingly presented from experts in surgical management, medical oncology, radiotherapy, pharmacokinetics, obstetric care, psychological care, neonatal and pediatric care. in addition a series of chapters focused on management in particular disease settings are presented, including breast cancer, melanoma, cervical cancer, ovarian tumors, lymphoma, leukemia, and thoracic cancers. the book reflects the major progress that has been achieved in the care of pregnant cancer patients in the recent years as important data have become available on patient management, and fetal safety in addition to valuable preclinical research on the impact of pregnancy on pharmacokinetics of anti-cancer agents. edited and authored by worldwide leaders in the field, it will serve as a valuable resource not only for oncologists but also for obstetricians, gynecologists, neonatologists, and pediatricians caring for pregnant cancer patients and their more

alternating electric fields therapy in oncology 2017 a practical guide to clinical applications of tumor treating fields

eric t. t. wong


this concise text provides a complete overview of alternating electric fields therapy — also known as tumor treating fields — for glioblastoma and other types of solid tumor malignancies. readers are given a fundamental understanding of this novel anti-cancer treatment modality by learning from clinical trial data as well as the physical and cell biology effects on tumor cells when alternating electric fields are applied both in vitro and in vivo. chapters illustrate the physics behind electric field propagation in space and other media. this is followed by a review of our current understanding of the electric field effects on dividing cells – including the disruption of cytokinesis, proper chromosome segregation and activation on the cell surface chaperons that induce immunogenic cell death. data from phase iii trials for the treatment of recurrent and newly diagnosed glioblastomas are included, as well as some of the ancillary post hoc analyses that were performed by various investigators.
the remainder of the chapter covers other solid tumor malignancies, including non-small cell lung cancer, pancreatic cancer and ovarian cancer, as this treatment modality is being applied to systemic malignancies. alternating electric fields therapy in oncology offers oncologists, neurologists, radiation oncologists, biomedical engineers, cell biologists and mitosis researchers the fundamentals needed for clinical more

dying and death in oncology 2017

lawrence berk


this book brings together in one volume many important topics about death and dying, including the pathophysiology of death, the causes of death among cancer patients, the ethics of death, the legal aspects of death for the physician and for the patient and caregivers, the economics of death, the medical management of the dying patient, including pain and dyspnea, the prediction of death, and the spiritual management of the dying patient. it also discusses other medical and humanistic aspects of death and dying, such as the historical definition of death and various cultures' and religions' viewpoints on death and the afterlife. everybody, including every patient with cancer, will die, and every physician will have to assist dying patients. oncologists face this prospect more often than many physicians. and yet to date there has been no comprehensive textbook on thanatology, the academic discipline studying death and dying, to assist oncologists in this difficult task. this book will help the physician to understand his or her own relationship with death and to communicate about death and dying with the patient and the patient's more